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The werewolf legend originated from the countryside around two German towns in 1591.  At that time Europe was under the dark shadow of ignorance and superstitions.  Towns were underdeveloped and people lived near woods.  The fear of wolves was like a nightmare.  Their attacks were so frequent that people even feared to travel from one place to another. Every morning, countryside people would find half-eaten human limbs on their fields.
The wolf frightens the humans because of its howling, its glow-in-the-dark yellow eyes, its hunting ability, its silent walking, and its nocturnal activity.
Werewolves are different then any other creature we know of.

A werewolf is a human that can voluntarily or involuntary change into a wolf, usually at night.  Another similar term for this is Lycanthropy.  When this effect takes place, the being's skin changes to a darker pigment and the body and facial hair grow out dramatically.  The nails of are said to grow longer and shaper, forming claws, turning the human into what some would call a "beast."   This powerful transformation only lasts during the night.
In most legends the human became a werewolf by either being born under a curse, usually a family curse, or being infected from the bite of another werewolf, but there are rituals that can be performed to turn oneself into a werewolf.   It was said that by the light of the moon, Witches would gather the ingredients necessary for transformation potions.   All ingredients in potions thought to effect transformations from human to beast were Berries of Yew, Purple Monkshood, Thorn Apple and tiny wreaths of Hemlock to mention only a few.  These recipes were powerful and would cause vivid hallucinations.
The concept of werewolves or lycanthropes is
possibly based on the myth of Lycaon. 

He was the King of Arcadia, and in the time of the ancient Greeks notorious for his cruelty.  He tried to buy the favor of Zeus by offering him the flesh of a young child.  Zeus punished him for this crime and turned him into a wolf.  The legends of werewolves have been told since the ancient Greeks and are known all over the world.  In areas where the wolf is not so common, the belief in werewolves is replaced by folklore where men can change themselves in tigers, lions, bears and other fierce animals.
LYCANTHROPIC DISORDER

Lycanthropic Disorder  is a mental condition in which the subject (called a Lycanthrope) believes that he or she is a werewolf.
The subject does not actually change shape, but is nevertheless capable of being as dangerous as an actual werewolf.
Most cases of supposed werewolf are really the works of Lycanthropic Disorder victims.
MAN TO BEAST

In real werewolves a physical change to wolf form does occur. The change can be voluntary (at will), or can be forced by certain cycles of the moon and certain sounds (such as howling).
WEREWOLVES & IMMORTALITY

Werewolves are immune from aging and from most physical diseases due to the constant regeneration of their physical tissue.  They can, therefore, be virtually immortal.  However, they can be killed by
any wound that destroys the heart or the brain.
THE MIND OF A WEREWOLF

Though primarily a true wolf while in wolf form, there is some proof that the werewolf retains enough knowledge to assist his killing; recognition of victims and human cunning have all been seen on werewolf cases.
BECOMING A WEREWOLF

There are several ways to become a werewolf.  They include being given the power of shape shifting through sorcery, being cursed by someone who you have wronged in some way (called Lycaeonia Curse), being bitten by a werewolf, and being born to a werewolf.
In each case, the blood becomes tainted or cursed.
DAMNATION

A person who becomes a werewolf against his will (birth, curse, or bite) is not completely damned until he tastes of human blood.
Once he does, his soul is eternally damned and nothing may
redeem him.  Even without tasting of human blood, however, as
long as the taint lies upon the immortal soul, it cannot enter Heaven, and will remain chained to the mortal plane upon death.

Myth or Fact . . . . . .
there are just some things we cannot explain.